Publications

Published

43.  Schuster-Little, N., Sokolovsky, A.D., Gentry, A., Saraf, A., Etzel, M.R., Patankar, M.S., and Whelan, R.J.  "Immunoaffinity-free chromatographic purification of ovarian cancer biomarker CA125 (MUC16) from blood serum enables mass spectrometry characterization," Anal. Meth. 2024, 16, 6337-6348. doi: 10.1039/D4AY01172D

42. Schuster-Little, N., McCabe, M., Nenninger, K., Safavi-Sohi, R., Whelan, R.J., and Hilliard, T.S.  "Generational diet-induced obesity remodels the omental adipose proteome in female mice," Nutrients, 2024, 16, 3086 (17 pages). doi: 10.3390/nu16183086

41. Hanson, E.K. and Whelan, R.J. "Combining the benefits of biotin-streptavidin aptamer immobilization with the versatility of Ni-NTA regeneration strategies for SPR," Sensors, 2024, 24, 2805 (15 pages). doi: 10.3390/s24092805

40. Wang, C., Weaver, S.D., Boonpattrawong, N., Schuster-Little, N., Patankar, M., and Whelan, R.J., "A revised molecular model of ovarian cancer biomarker CA125 (MUC16) enabled by long-read sequencing." Cancer Res. Comm., 2024, 4, 253–263. doi: 10.1158/2767-9764

39. Hanson, E.K., Wang, C., Minkoff, L., and Whelan, R.J., "Strategies for mitigating commercial sensor chip variability with experimental design controls." Sensors, 2023, 23, 6703 (13 pages). doi: 10.3390/s23156703

38. Hanson, E.K. and Whelan, R.J. “Application of the Nicoya OpenSPR to studies of biomolecular binding: a review of the literature from 2016 to 2022,” Sensors, 2023, 23, 4832 (22 pages). doi: 10.3390/s23104831

37. Wang, C., Hanson, E.K., Minkoff, L., and Whelan, R.J. “Individual recombinant repeats of MUC16 display variable binding to CA125 antibodies,” Cancer Biomarkers, 2023, 37, 85–94. doi: 10.3233/CBM-220191

36. Claus, M.J., Gionfriddo, E., Monahan, J., Whelan, R.J., and Vitha, M.F. “Threshold Concepts in Analytical Chemistry,” J. Chem. Educ., 2023, 100, 427–431. doi: 10.1021/acs.jchemed.2c00674

35. DeRosa, C.M., Weaver, S.D., Wang, C., Schuster-Little, N., and Whelan, R.J. “Simultaneous N-deglycosylation and digestion of complex samples on S-Traps enables efficient glycosite hypothesis generation,” ACS Omega, 2023, 8, 4410–4418. doi: 10.1021/acsomega.2c08071

34. Weaver, S.D., Schuster-Little, N., and Whelan, R.J “Preparative capillary electrophoresis (CE) fractionation of protein digests improves protein and peptide identification in bottom-up proteomics,” Anal. Meth., 2022, 14, 1103–1110. (Featured on the cover) doi: 10.1039/d1ay02145a

33. Weaver, S.D., Ambrose, G.A., and Whelan, R.J. “Activity: Teaching Coding in R through Discipline-Focused Problem-Solving in an Analytical Chemistry Course,” J. Chem. Educ., 2022, 99, 3068-3073. doi: 10.1021/acs.jchemed.2c00395

32. Sherman, L.M., Findley, M.D., Borsari, R.K., Schuster-Little, N., Strausser, S.L., Whelan, R.J., Jenkins, D.M., and Camden, J.P. “N-Heterocyclic carbene ligand stability on gold nanoparticles in biological media,” ACS Omega, 2022, 7, 1444–1451. doi: 10.1021/acsomega.1c06168

31. Mace, C., Morrin, A., and Whelan, R.J. “Introduction to bioanalytical sensors for real-world applications,” Anal. Meth., 2021, 13, 1776. doi: 10.1039/D1AY90015C

30. Weaver, S.D. and Whelan, R.J. “Characterization of DNA aptamer-protein binding using fluorescence anisotropy assays in low-volume, high-efficiency plates,” Anal. Meth., 2021, 13, 1302–1307. (Featured on the cover) doi: 10.1039/D0AY02256J

29. Schuster-Little, N., Fritz-Klaus, R., Etzel, M., Patankar, N., Javeri, S., Patankar, M.S., Whelan, R.J. “Affinity-free enrichment and mass spectrometry analysis of the ovarian cancer biomarker CA125 (MUC16) from patient-derived ascites,” Analyst, 2021, 146, 85–94. (Featured on the cover) doi: 10.1039/D0AN01701A

28. Schuster-Little, N., Madera, S., Whelan, R.J. “Developing a mass spectrometry-based assay for the ovarian cancer biomarker CA125 (MUC16) using suspension trapping (S-trap)," Anal. Bioanal. Chem., 2020, 412, 6361–6370. (Invited to the special issue: “Female Role Models in Analytical Chemistry”) doi: 10.1007/s00216-020-02586-9

27. Garvin, M.C., Schijf, J., Kaufman, S.R., Konow, C., Liang, D., Nigra, A.E., Stracker, N.H., Whelan, R.J., Wiles, G.C. “A survey of trace metal burdens in increment cores from eastern cottonwood across a childhood cancer cluster, Sandusky County, OH, USA,” Chemosphere, 2020, 238, 124528. doi: 10.1016/j.chemosphere.2019.124528

26. Mears, K.S., Markus, D.L., Ogunjimi, O., Whelan, R.J. “Experimental and mathematical evidence that thrombin-binding aptamers form a 1 aptamer: 2 protein complex,” Aptamers, 2018, 2, 64–73. PMC8372783

25. Garvin, M.C., Austin, A., Boyer, K., Gefke, M., Wright, C., Pryor, Y., Soble, A., Whelan, R.J. “Attraction of Culex pipiens to house sparrows is influenced by host age but not uropygial gland secretions,” Insects, 2018,9, 127. doi: 10.3390/insects9040127

24. Alharbi, Y, Patankar, M.S., and Whelan, R.J. “Antibody based therapy for ovarian cancer,” In Ovarian Cancer Immunotherapy: Current Perspectives; Farghaly, S., Ed.; Oxford University Press: Oxford, 2018. (invited) doi: 10.1093/med/9780190248208.001.0001

23. Garvin, M.C., Austin, A.L, Stracker, N.H., Slowinski, S.P. Rutter, J.E., Butler, M., Michel, M., Whelan, R.J. “Attraction of Culex pipiens to uropygial gland secretions does not explain feeding preference for American robins,” J. Vector Ecol., 2018, 43, 110–116. doi: 10.1111/jvec.12290

22. Pires, T.A., Narovec, C.M., Whelan, R.J. “Effects of cationic proteins on gold nanoparticle/aptamer assays,” ACS Omega, 2017, 2, 8222–8226. doi: 10.1021/acsomega.7b01336

21. Scoville, D.J., Uhm, T.K.B., Shallcross, J.A., Whelan, R.J. “Selection of DNA aptamers for ovarian cancer biomarker CA125 using One-Pot SELEX and high-throughput sequencing,” J. Nucl. Acids, 2017, Article ID 9879135, 9 pages, 2017. doi: 10.1155/2017/9879135

20. Ricker, A.S. and Whelan, R.J. “Reading, Writing, and Peer Review: Engaging with Chemical Literature in a 200-Level Analytical Chemistry Course,” in Integrating Information Literacy into the Chemistry Curriculum. Editors: C.F. Lovit, K. Shuyler, Y.Li. ACS Symposium Series Vol. 1232, 2016. doi: 10.1021/bk-2016-1232

19. Kapur, A., Felder, M., Fass, L., Kaur, J., Czarnecki, A., Rathi, K., Zeng, S., Osowski, K.K. Howell, C., Xiong, M.P., Whelan, R.J., Patankar, M.S. “Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation,” Sci. Rep., 2016, 6, 27530. doi: 10.1038/srep27530

18. Eaton, R.M., Shallcross, J.A., Mael, L.E., Mears, K.S., Minkoff, L., Scoville, D.J., Whelan, R.J. “Selection of DNA aptamers for ovarian cancer biomarker HE4 using CE-SELEX and high-throughput sequencing,” Anal. Bioanal. Chem., 2015, 407, 6965–6973. doi: 10.1007/s00216-015-8665-7

17. Felder, M., Kapur, A., Gonzalez-Bosquet, J., Horibata, S., Heintz, J., Albrecht, R., Faas, L., Kaur, J., Hu, K., Shojaei, H., Whelan, R.J., Patankar, M.S. “MUC16 (CA125): Tumor biomarker to cancer therapy, a work in progress,” Molecular Cancer, 2014, 13, 129. (A “highly accessed” article, with >50,00 views as of 7/2023) doi: 10.1186/1476-4598-13-129

16. Liu, Y., Whelan, R.J., Pattnaik, B.R., Ludwig, K., Subudhi, E., Rowland, H., Claussen, N., Zucker, N., Uppal, S., Kushner, D.M., Felder, M., Patankar, M.S., and Kapur, A. “Terpenoids from Zingiber officinale (Ginger) Induce Apoptosis in Endometrial Cancer Cells through the Activation of p53,” PLoS ONE,  2012, 7 (12): e53178. doi: 10.1371/journal.pone.0053178

15. Shaw, C.L., Rutter, J.E., Austin, A.L., Garvin, M.C., and Whelan, R.J. “Volatile and Semivolatile Compounds in Gray Catbird Uropygial Secretions Vary with Age and between Breeding and Wintering Grounds,” J. Chem. Ecol., 2011, 37, 329–339. (Featured on the cover) doi: 10.1007/s10886-011-9931-6

14. Berman, Z.T., Moore, L.J., Knudson, K.E., and Whelan, R.J. “Synthesis and Structural Characterization of the Peptide Epitope of the Ovarian Cancer Biomarker CA125 (MUC16),” Tumor Biol., 2010, 31, 495–502. doi: 10.1007/s13277-010-0062-4

13. Whelan, R.J., Levin, T.C., Owen, J.C., and Garvin, M.C. “Short-chain Carboxylic Acids from Gray Catbird (Dumetella carolinensis) Uropygial Secretions Vary with Testosterone Levels and Photoperiod,” Comp. Biochem. Physiol. B, 2010, 156, 183–188. doi: 10.1016/j.cbpb.2010.03.005

12. Noroski, J. and Whelan, R.J. Instructor Solutions Manual for Chemistry: Principles, Patterns, and Applications; Benjamin Cummings: San Francisco, 2007.

11. Yang, P., Whelan, R.J., Mao, Y., Lee, A. W.-M., Carter-Su, C., and Kennedy, R.T. “Multiplexed Detection of Protein-Peptide Interaction and Inhibition Using Capillary Electrophoresis,” Anal. Chem., 2007, 79, 1690–1695. doi: 10.1021/ac061936e

10. Yang, P., Whelan, R.J., Jameson, E.E., Kurzer, J.H., Argetsinger, L.S., Carter-Su, C., Kabir, A., Malik, M., and Kennedy, R.T. “Capillary Electrophoresis and Fluorescence Anisotropy for Quantitative Analysis of Rapid Peptide-Protein Interactions using JAK2 and SH2-Bβ as a Model System,” Anal. Chem., 2005, 77, 2482–2489. doi: 10.1021/ac048307u

9. Whelan, R.J., Hannon, T.E., Rakestraw, D.J., and Zare, R.N. “Application of Ion Chromatography to the Investigation of Real-World Samples,” J. Chem. Educ., 2004, 81, 1299–1302. doi: 10.1021/ed081p1299

8. Whelan, R.J., Sunahara, R.K., Neubig, R.R., and Kennedy, R.T. “Affinity Assays using Fluorescence Anisotropy with Capillary Electrophoresis Separation,” Anal. Chem., 2004, 76, 7380–7386. doi: 10.1021/ac0489566

7. Wheeler, A.R., Chah, S., Whelan, R.J., and Zare, R.N. “Poly(dimethylsiloxane) Microfluidic Flow Cells for Surface Plasmon Resonance Spectroscopy,” Sens. Actuat. B, 2004, 98, 208–214. doi: 10.1016/j.snb.2003.06.004

6. Whelan, R.J. and Zare, R.N. “Teaching Effective Communication in a Writing-Intensive Analytical Chemistry Course,” J. Chem. Educ., 2003, 80, 904–906. doi: 10.1021/ed080p904

5. Whelan, R.J. and Zare, R.N. “Single-Cell Immunosensors for Protein Detection,” Biosens. Bioelectron., 2003, 19, 331–336. doi: 10.1016/S0956-5663(03)00190-8

 

4. Wheeler, A.R., Throndset, W.R., Whelan, R.J., Leach, A.M. Zare, R.N., Liao, Y.H., Farrell, K., Manger, I.D., and Daridon, A. “Microfluidic Device for Single Cell Analysis,” Anal. Chem., 2003, 75, 3249–3254. doi: 10.1021/ac0340758

3. Whelan, R.J. and Zare, R.N. “Surface Plasmon Resonance Detection for Capillary Electrophoresis Separations,” Anal. Chem., 2003, 75, 1542–1547. doi: 10.1021/ac0263521

2. Whelan, R.J., Wohland, T., Neumann, L., Huang, B., Kobilka, B.K, and Zare, R.N. “Analyzing Biomolecular Interactions Using a Miniaturized Surface Plasmon Resonance Sensor,” Anal. Chem., 2002, 74, 4570–4576. doi: 10.1021/ac025669y

1. Neumann, L., Wohland, T., Whelan, R.J., Zare, R.N., Kobilka, B.K. “Functional Immobilization of a Ligand-Activated G Protein Coupled Receptor,” ChemBioChem., 2002, 3, 993–998. doi: 10.1002/1439-7633(20021004)3:10<993::AID-CBIC993>3.0.CO;2-Y